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Re: Adding Parnate and prazosin. » ed_uk2010

Posted by SLS on February 5, 2012, at 15:18:19

In reply to Re: Adding Parnate and prazosin. » SLS, posted by ed_uk2010 on February 5, 2012, at 13:31:00

> >Latuda did not produce acceptable results.
>
> I'm sorry to hear that. It's good that you tried it though. Have you tried asenapine Scott? I don't recall.

Yes, I tried asenapine. It didn't help, but it seemed like a rather benign drug, otherwise. I remained on Abilify while taking it, though. I can't be sure that asenapine would not have been an effective substitute for Abilify. I wasn't looking for a substitute back then, though. If I had responded amazingly well to asenapine, I would then have attempted to discontinue Abilify.

I am pretty sure that it is the dopamine D2/D3 receptor partial agonist properties of Abilify that is responsible for its beneficial effects on me. Abilify is unique in this regard, so I guess I'm stuck with it. There is a compound, OPC-34712, currently under investigation as an antidepressant that is a D2 receptor partial agonist. However, it is without effect on D3 receptors. I think partial agonism at both receptors is important to produce an antidepressant effect. I hope not, though. It would be great if OPC-34712 turned out to be an effective substitute for Abilify without increasing my triglyceride and producing weight gain.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1005781
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