Posted by SLS on January 29, 2012, at 6:41:52
In reply to Re: Adding Parnate and prazosin. » SLS, posted by sigismund on January 28, 2012, at 19:27:24
> Scott, can you explain something for me?
Probably not, but I'll try.
> The ADs you have taken have increased NE (so to speak) and the prazosin blocks it (or something like that).
Yes. Prazosin blocks NE alpha-1 receptors.
> It just seems back the front, if you see what I mean.
Yes. That's why I don't pay too much attention to theories anymore when it comes to choosing drugs for treatment. Theories are sometimes valuable to include drugs for consideration, but not for their exclusion.
I offered my doctor one possible explanation in an email I sent him:
"It occurred to me that prazosin might quiet those neurons that are observed to be hyperactive in cingulate cortex (Brodmann areas 24, 25) in indviduals with MDD. If so, it would effectively mimic DBS."
This is really nothing more than a wild guess for which I have little evidence to support. However, NE alpha-1 receptors do exist in the regions I specified.
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw