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Re: +++ MAO-A or B ? Gerovital (procaine) selectivity Marty

Posted by SLS on June 28, 2008, at 16:12:55

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity Phillipa, posted by Marty on June 28, 2008, at 12:51:35

> > Marty well you know I can't maybe link or Scott will know. Good luck you smart intelligent person. Can you share? Love Phillipa
>
> Thanks for the compliment Phillipa. Can't be sure (and doesn't want to be) if I'm that smart or not but I would be willing to trade some of that brain for some of your heart, anytime.
>
> I wish Link or Scott would take a couple minutes to check it out but I'll try to find out again before 'yelling' their name, asking their help, in a new thread subject like "SLS/LINK -> Plz help!!" :P
>

Procaine was used experimentally at the NIH as a test reagent to be monitored by PET scan. There are some people who, when given procaine I.V., knew their only experience of relief from refractory depression. It would only last a fraction of an hour, though. Many people experienced changes in mood and perception that were intense. Procaine can cause psychosis. There are quite a few ways this drug can be used, as there are so many properties that it possesses.

I am unimpressed with the degree of MAO inhibition procaine produces. It is weak and reversible. I am more impressed with some of the cholinergic explanations of procaine when trying to understand the emotional and perceptual changes that it elicits.

http://www.nature.com/npp/journal/v29/n7/abs/1300404a.html

On the other hand, Gerovital doesn't seem to harm anyone. I know it is somehow different from standard i.v. procaine.

It is hard for me to be enthused about procaine given some of the bizarre reactions that I saw at the NIH. Fortunately, I was not in the department that was investigating it.

Unless you have found something documented about the use of procaine to treat depression, I would suggest that you go to other things first. I don't think it has the degree of MAO inhibition that you thought it did.


- Scott

 

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