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Re: +++ MAO-A or B ? Gerovital (procaine) selectivity Marty

Posted by SLS on June 28, 2008, at 16:12:55

In reply to Re: +++ MAO-A or B ? Gerovital (procaine) selectivity Phillipa, posted by Marty on June 28, 2008, at 12:51:35

> > Marty well you know I can't maybe link or Scott will know. Good luck you smart intelligent person. Can you share? Love Phillipa
> Thanks for the compliment Phillipa. Can't be sure (and doesn't want to be) if I'm that smart or not but I would be willing to trade some of that brain for some of your heart, anytime.
> I wish Link or Scott would take a couple minutes to check it out but I'll try to find out again before 'yelling' their name, asking their help, in a new thread subject like "SLS/LINK -> Plz help!!" :P

Procaine was used experimentally at the NIH as a test reagent to be monitored by PET scan. There are some people who, when given procaine I.V., knew their only experience of relief from refractory depression. It would only last a fraction of an hour, though. Many people experienced changes in mood and perception that were intense. Procaine can cause psychosis. There are quite a few ways this drug can be used, as there are so many properties that it possesses.

I am unimpressed with the degree of MAO inhibition procaine produces. It is weak and reversible. I am more impressed with some of the cholinergic explanations of procaine when trying to understand the emotional and perceptual changes that it elicits.

On the other hand, Gerovital doesn't seem to harm anyone. I know it is somehow different from standard i.v. procaine.

It is hard for me to be enthused about procaine given some of the bizarre reactions that I saw at the NIH. Fortunately, I was not in the department that was investigating it.

Unless you have found something documented about the use of procaine to treat depression, I would suggest that you go to other things first. I don't think it has the degree of MAO inhibition that you thought it did.

- Scott




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