Posted by bulldog2 on April 29, 2008, at 8:40:10
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on April 28, 2008, at 20:11:50
> > 1.25mg sublingual citrate = approx. 10mg oral hydrochloride?
> >
>
> No, sublingual hydrochloride.
>
> > Wow, no wonder such a difference in effects is reported between the two forms.
> >
> > Interesting thought: everybody who's done any amount of research on selegiline has come across the rat (and other mammal) studies where selegiline extended potential life span so dramatically. My question is this - what was the method of administration and exact formulation (citrate, hyrochloride, freebase in saline solution, or some other form entirely?) of the drug in those studies? If I had to guess I'd say that injection was the route of administration, and if that's the case then the more direct the route of administration the better (i.e. injection > patch > sublingual > oral). Hmmmmmm.
> >
>
> Sublingual beats transdermal (the sublingual tissue is more permeable than regular skin).
>
> Dr. Knoll used subcutaneous injections of 0.25 mg/kg L-deprenyl three times a week in his famous experiment where some of the selegiline-treated rats lived longer than the documented maximum life span of the rat strain in question. The abstract doesn't mention which form was used, but I presume it was the hydrochloride, because it's stable and readily soluble in water, whereas the freebase is reportedly volatile and poorly soluble.
>
> It appears that the EMSAM patches use the freebase, which is a yellow to colourless oily liquid.
>
> From what I've been able to discern, the so-called liquid selegiline citrate products are actually the freebase stabilised with citric acid and possibly other preservatives. In fact, I've been unable to find any proof of the existence of other forms of selegiline than the hydrochloride salt and freebase, although it would almost certainly be possible to produce some.
>
> Some liquid selegiline products are reportedly mere aqueous solutions of the hydrochloride.
>
> What is your liquid selegiline like? Is it an oily yellowish liquid, or does it seem more like water?I believe the 1.25 to 10 ratio is for zelapar the new sublingual tablet for pd. So we don't know if the liquids are absorbed that well.
On a more disconcerting note Discovery who made the first liquid depreynyl citrate which is now off the market claims that selepryl and ceprenyl are fakes and are just liquid selegiline hcl.
I wrote the company that makes these meds and asked them about that and have not heard from them yet.
poster:bulldog2
thread:825078
URL: http://www.dr-bob.org/babble/20080420/msgs/826219.html