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Re: A few Cyprenil (liquid selegiline citrate) ?s

Posted by bulldog2 on April 26, 2008, at 23:29:19

In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on April 26, 2008, at 22:23:12

> >
> > Anyone have any idea how much of the deprenyl is absorbed under the tongue? If there is a high conversion rate you could use the liquid as an AD and get mao-a inhibition. I hated the patch as you only have three sizes and they left big blotches and was just inconvenient. With the drops you can titrate more conviently.
> >
>
> One study found that 1.25 mg sublingual Zydis selegiline was equivalent to 10 mg of oral (swallowed) selegiline tablets, in terms of plasma selegiline contrentrations, while metabolite levels were much lower for the sublingual form.

we know that 10 mg of oral deprenyl by itself is considered safe and is basically an mao-b inhibitor. I haven't seen any studies comparing cyprenil to the oral form. So who knows what the ratio between the two forms is. We know that we have to get into the 40 - 60 range with the tablets to inhibit mao-a enough to be meaningful.I believe the tablets have an absorption rate of about 10 % would like to find the rate for liquid deprenyl.

 

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