Posted by bulldog2 on April 27, 2008, at 9:32:40
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Alucard on April 27, 2008, at 1:49:08
> 1.25mg sublingual citrate = approx. 10mg oral hydrochloride? Wow, no wonder such a difference in effects is reported between the two forms.
>
> Interesting thought: everybody who's done any amount of research on selegiline has come across the rat (and other mammal) studies where selegiline extended potential life span so dramatically. My question is this - what was the method of administration and exact formulation (citrate, hyrochloride, freebase in saline solution, or some other form entirely?) of the drug in those studies? If I had to guess I'd say that injection was the route of administration, and if that's the case then the more direct the route of administration the better (i.e. injection > patch > sublingual > oral). Hmmmmmm.The problem with the patch is there are only three sizes so there's not room for titration. Plus I found they fell off last summer when I sweated during exercise. Like to see zelapar used for depression. I imagine it would work like the patch since it bypasses the stomach and liver first pass.
poster:bulldog2
thread:825078
URL: http://www.dr-bob.org/babble/20080420/msgs/825787.html