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Re: A few Cyprenil (liquid selegiline citrate) ?s

Posted by undopaminergic on May 2, 2008, at 12:26:23

In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by alucard on May 1, 2008, at 2:11:12

> I agree with you guys that Cyprenil and Selepryl could quite easily be selegiline HCl, especially given the "flexibility" of Mexican pharmaceutical purity and labeling standards. However, as a chemist I know that it just isn't that difficult to make the citrate form if you've already got a lab equipped to make the hydrochloride form. So why lie about it?
>

Perhaps they don't have a lab equipped to synthesise selegiline, or perhaps they don't have the skills? Perhaps they just buy it from bulk chemical suppliers? In that case they will find the hydrochloride to be the most readily available, whereas the freebase is quire rare, and the citrate absolutely unheard of.

Also, since the properties of the citrate salt of selegiline are unknown, we don't know whether it's water soluble or otherwise suitable for bottling and distribution.

Since you're a chemist, have you considered trying to make your own selegiline - citrate or otherwise? Aren't you at least tempted to evaporate the water from some of your Cyprenil and determine the melting point of the residue? And perhaps hydrolyse it with a base and see whether you get the oily free base of selegiline? Maybe you even have some contacts within the industry who could help you with HPLC, GCMS, or other advanced methods of analysis?


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