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Re: Still confused-Larry Cecilia

Posted by Larry Hoover on September 4, 2007, at 10:46:29

In reply to Still confused-Larry, posted by Cecilia on September 4, 2007, at 1:46:43

> Now I'm even more confused. I thought your earlier post said that if I lacked this enzyme hydrocodone wouldn't work for me and the 2nd one said you were surprised it didn't.

I'm sorry if I'm contributing to the confusion. The enzyme issue and binding affinity are in the statistical realm. They are useful for prediction, but individual experience trumps the stats. Looking at the tabulated data for mu opioid receptor binding, it would appear that hydrocodone should offer some analgesia, even with zero function at 2D6. Your experience was that you got no pain relief from it, but still experienced the expected side effects. That would make a dose increase impractical, and does suggest that a painkiller with -morph- in its name might be necessary, in your case. I share your experience to a large degree, but oxycodone does work for me. I have never tried hydrocodone.





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