Psycho-Babble Medication | about biological treatments | Framed
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More questions for Larry

Posted by Cecilia on August 31, 2007, at 2:06:45

In reply to Re: Getting Doctors to prescribe opiates Larry Hoover, posted by Cecilia on August 29, 2007, at 2:34:37

I've been trying to find more info on this CYP2D6 enzyme, and it seems like pretty much all the pain meds and most antidepressants are metabolized by it. Which may explain why I've had no depression relief from any of the many many antidepressants I've tried and bad side effects from most. Interestingly the two that had no side effects (though no benefits either) one, celexa, doesn't appear to use CYP2D6, the other trazodone, does. The ADs with the worst side effects for me were Effexor, Cymbalta, various tricyclics and all the MAO's, Effexor, Cymbalta and tricyclics all use CYP2D6, couldn't find any info on the MAO's. As for pain meds, oxycodone, also appears to use CYP2D6, but you say it still works for people with a deficiency in this enzyme? I'm confused. I guess the 1st thing is to see if I can convince my doctor to figure out if I really am deficient in this enzyme, though it sure sounds like it from my reaction to Vicodin. I've given up hope of ever finding anything that would work for depression, but it sure would be nice to be in less pain from my severe arthritis. Cecilia




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