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Re: paracetamol/acetominophen hepatoxicity Deus_Abscondis

Posted by Larry Hoover on September 3, 2007, at 16:25:05

In reply to Re: Getting Doctors to prescribe opiates, posted by Deus_Abscondis on September 2, 2007, at 1:29:14

> So I take 4 grams of paracetamol every four waking hours.

There's a whole lot more in your post than this sentence worth commenting on, but I wanted to jump to this issue....that amount of acetominophen/paracetamol is very likely to be above your liver's capacity. The daily intake limit is 4 grams, and chronic use at even that level can be hepatotoxic.

In small doses, paracetamol is metabolized by conjugation, but those pathways are easily saturated. In large doses, one molecule of paracetamol requires one molecule of glutathione to detoxify a toxic intermediate called NAPQI, but there is a limited supply of glutathione. Once glutathione is depleted, liver cells are programmed to die, a process called apoptosis. If you are going to maintain that level of liver stress, you must supplement proportionally with glutathione precursors. Hospitals administer N-acetyl cysteine in cases of paracetamol toxicity, and you can do the same. Paracetamol and NAC have roughly the same molecular weight, so if you're taking 4 grams of paracetamol, I'd recommend 4 grams of NAC, taken at the same time.





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