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Re: effect of melatonin on seratonin? » iforgotmypassword

Posted by zeugma on October 31, 2006, at 17:57:37

In reply to effect of melatonin on seratonin?, posted by iforgotmypassword on October 30, 2006, at 12:52:55

> MAIN QUESTION: does anyone know if melatonin reduces seratonin activity anywhere, at specific receptors, or just in general? or does it increase seratonin?

Melatonin probably lowers serotonin levels in many regions of the brain. Serotonin levels are highest during wakefulness, and melatonin levels are highest in the period of drowsiness leading to sleep, in what was probably the normal course of things before Edison, 12 hours after the first exposure to significant amounts of sunlight (an hour or so after sunrise?).
>
>
> i am replacing all lights in my house with yellow "bug" lights (to hopefully block the blue) so i can actually sleep given all the time i spend in bed. i always have to sleep with the light on due to fear and general anxiety. yellow aparently does not cancel out melatonin production. blue does.>>

this is interesting. The receptors in the retina that are sensitive to blue and yellow light are said to be dopaminergic (probably D2) receptors. I have extreme color-insensitivity, in fact unless on a significant dose of Ritalin I can barely process color at all. (Don't hire me to decorate your house.) Now besides Luvox, the class of meds that tends to produce circadian sleep disorders is the D2 antagonists, a.k.a. typical antipsychotics. Atypicals such as Risperdal are much less prone to this effect, probably because the 5-HT2A antagonism (which seems to promote normal melatonin release) counteracts the D2 antagonism and consequent retinal insensitivity to yellow- which is, more or less, the color of the sun. Ritalin actually helped me with circadian issues more than any other med. it certainly helped me see color.

>
> another huge factor is if it reduces seratonin, it may help my bruxism and akithisic feelings, and hopefully reduce apathy and give energy. (and less catecholamine and acetylcholine suppesion?)
>

Buspar is actually somewhat helpful with bruxism issues. So is Klonopin, and benzodiazpines stimulate melatonin release.

-z


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URL: http://www.dr-bob.org/babble/20061028/msgs/699401.html