Posted by linkadge on October 31, 2006, at 6:33:45
In reply to Re: effect of melatonin on seratonin? » iforgotmypassword, posted by zeugma on October 30, 2006, at 16:35:11
Zeugma, I didn't realize melatonin was a presynaptic autoreceptor agoinst. I knew it worked to potentiate postsynaptic 5-ht1a responces.
Anyhow, I'd heard that melatonin blocks the antidepressant effect of SSRI's, but never heard that serotonin blocks the antidepressant effect of melatonin.
Serotonin and melatonin work at kind of a yin yang, via 5-ht2a as zeugma mentioned. Drugs that block 5-ht2a (like mirtazapine for instance), generally have melatonergic properties.Melatonin itself can sometimes be depressogenic.
Long term blockade of melatonin excretion is probably a bad thing. Sudies of situations where people have reduced melatonin output (night shift workers) have found links to cancers etc. Some question the long term use of SSRI's for these reasons.
Linkadge
poster:linkadge
thread:699037
URL: http://www.dr-bob.org/babble/20061028/msgs/699238.html