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Re: Nicotine and Depression Questionmark MrBrice

Posted by Questionmark on October 6, 2006, at 16:41:42

In reply to Re: Nicotine and Depression Questionmark, posted by MrBrice on October 6, 2006, at 15:51:19

"> Aren't you speaking contradictious here? The nicotine raises the dopamine and thus gives a feeling of calm- and contentness.
Nardil also raises the dopamine levels, so one would expect it to have similar's a >reasonnable theory right?
> greets,
> Brice "

> > >-
> > The two drugs work very differently.
> >
> >
> > - Scott
> >
> >
> so, there's no indication here that nardil would be a good drug for me? Istn't the nicotine working an indicator?
> grtz

Not at all really. In fact, Nardil is highly serotonergic and ultimately not very dopaminergic. Although still much different, an SSRI would probably give one of the best indications as to how you would react with Nardil. But Nardil is a complicated drug and has much more wide ranging effects than SSRIs, including effects on NE, epinephrine, GABA, and even alanine, as well as serotonin and dopamine. (Incidentally it probably has a more potent effect on NE than DA, too). But in my opinion it is more similar to the SSRIs than it is to other drugs (except some other MAOIs like Marplan)-- probably even Parnate.

Nicotine is probably more related to Parnate than Nardil, as Parnate is more stimulatory and highly dopaminergic. But even so, dopamine has a wide array of effects and roles in the brain and in my opinion is a very complicated neurotransmitter. *** One drug that stimulates dopamine release can be much different than another that does. In fact, almost all if not all addictive substances increase dopamine output (in the reward centers of the brain)-- from opiates to amphetamines to nicotine and alcohol-- but many of these are of course extremely different substances, with the only real commonality being that they can induce euphoria.
And in my own experience I know that DA *agonists* are subjectively much much different than psychostimulants, which increase dopamine release [among other things] (directly or through reuptake inhibition or both)-- and in theory BOTH should result in the activation of more dopamine receptors & should consequently have quite similar effects.. but that is not the case.

So, basically my point of this long tangent is that your reaction to nicotine can really tell you very little if anything about what your reaction to MAOIs or other drugs will be, particularly Nardil. The only thing it will tell you is how you will react to drugs that stimulate nicotine receptors.

... (Oh, which reminds me-- you might want to look into galantamine, of which I have no experience but which is believed to sensitize nicotinic receptors. It is primarily a cholinesterase inhibitor as are other Alzheimer's drugs, so it is also probably much different than nicotine and may not be beneficial, but it's something to look into. It's also not approved in the U.S. [as a pharmaceutical-- there are herbal supplements you can find it in], but it is in other countries.)




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