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Re: interesting- re clonazepam and 5-HT transporter » zeugma

Posted by jedi on April 23, 2006, at 0:00:47

In reply to interesting- re clonazepam and 5-HT transporter, posted by zeugma on April 20, 2006, at 20:08:27

>
> Selective central benzodiazepine agonists, such as clonazepam, are known to modify serotonin and 5-hydroxyindoleacetic content in the brain. In order to further study the effect of this benzodiazepine on serotonin turnover rate, rats received clonazepam, 10 mg/kg for 10 days, and the concentrations of serotonin and 5-hydroxyindoleacetic acid were determined in the hippocampus after inhibition of monoamineoxidase with pargyline. ...

Hi,
10mg/kg would be like a 220lb person taking 1000mg daily of clonazepam for 10 days. Unless I'm reading this wrong, sounds like enough benzo to knock off a horse, much less a rat. How can anything be inferred from such high dosages.
Jedi


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URL: http://www.dr-bob.org/babble/20060417/msgs/636025.html