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Re: Prozac impairs the clearance of Alprazolam (Xa » SLS

Posted by yxibow on March 31, 2006, at 15:44:17

In reply to Re: Prozac impairs the clearance of Alprazolam (Xa » rjlockhart, posted by SLS on March 29, 2006, at 14:21:04

> Hi Matt.
>
> What the abstract is saying is that Prozac makes Xanax stay in the body longer, but does not do this to Klonopin. The interaction is modest at best.
>
> Prozac acts to inhibit (slow-down) an enzyme called CYP450-3A. Ordinarily, this enzyme acts to metabolize (break down) Xanax so that the body can eliminate it (clearance). Prozac prevents this from happening to some degree.
>
>
> - Scott

3A4 is largely discounted in the PI and the fairly substantial list at

http://medicine.iupui.edu/flockhart/clinlist.htm

the entire interactions are at

http://medicine.iupui.edu/flockhart/table.htm

Prozac does however inhibit certain drugs at a clinical level at 2D6, which does not affect common benzodiazepines.

Luvox, fluvoxamine, however, is known to affect 3A4, which affects the level of alprazolam and diazepam (Xanax, Valium).

-- Jay

 

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