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Re: Prozac impairs the clearance of Alprazolam (Xa » rjlockhart

Posted by SLS on March 29, 2006, at 14:21:04

In reply to Prozac impairs the clearance of Alprazolam (Xanax), posted by rjlockhart on March 29, 2006, at 12:28:30

Hi Matt.

What the abstract is saying is that Prozac makes Xanax stay in the body longer, but does not do this to Klonopin. The interaction is modest at best.

Prozac acts to inhibit (slow-down) an enzyme called CYP450-3A. Ordinarily, this enzyme acts to metabolize (break down) Xanax so that the body can eliminate it (clearance). Prozac prevents this from happening to some degree.


- Scott

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1424422&dopt=Abstract
>
> what does this mean.
>
> I read in the article it was successful with clonazepam but not alprazolam.
>
> I take Xanax, and Prozac 20mg
>
> Im starting to read all these trial articles.
>
> Anyways, can anyone explain, or know what that means?
>

 

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