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Dr. Bob is Robert Hsiung, MD,
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Posted by rjlockhart on March 29, 2006, at 12:28:30
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1424422&dopt=Abstract
what does this mean.
I read in the article it was successful with clonazepam but not alprazolam.
I take Xanax, and Prozac 20mg
Im starting to read all these trial articles.
Anyways, can anyone explain, or know what that means?
Matt
Posted by SLS on March 29, 2006, at 14:21:04
In reply to Prozac impairs the clearance of Alprazolam (Xanax), posted by rjlockhart on March 29, 2006, at 12:28:30
Hi Matt.
What the abstract is saying is that Prozac makes Xanax stay in the body longer, but does not do this to Klonopin. The interaction is modest at best.
Prozac acts to inhibit (slow-down) an enzyme called CYP450-3A. Ordinarily, this enzyme acts to metabolize (break down) Xanax so that the body can eliminate it (clearance). Prozac prevents this from happening to some degree.
- Scott> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1424422&dopt=Abstract
>
> what does this mean.
>
> I read in the article it was successful with clonazepam but not alprazolam.
>
> I take Xanax, and Prozac 20mg
>
> Im starting to read all these trial articles.
>
> Anyways, can anyone explain, or know what that means?
>
Posted by Phillipa on March 29, 2006, at 21:36:53
In reply to Re: Prozac impairs the clearance of Alprazolam (Xa » rjlockhart, posted by SLS on March 29, 2006, at 14:21:04
Scott you beat me to the punch I had actually figured that out and was going to post the same thing. So yes Matt it is true. Love Mom2
Posted by yxibow on March 31, 2006, at 15:44:17
In reply to Re: Prozac impairs the clearance of Alprazolam (Xa » rjlockhart, posted by SLS on March 29, 2006, at 14:21:04
> Hi Matt.
>
> What the abstract is saying is that Prozac makes Xanax stay in the body longer, but does not do this to Klonopin. The interaction is modest at best.
>
> Prozac acts to inhibit (slow-down) an enzyme called CYP450-3A. Ordinarily, this enzyme acts to metabolize (break down) Xanax so that the body can eliminate it (clearance). Prozac prevents this from happening to some degree.
>
>
> - Scott3A4 is largely discounted in the PI and the fairly substantial list at
http://medicine.iupui.edu/flockhart/clinlist.htm
the entire interactions are at
http://medicine.iupui.edu/flockhart/table.htm
Prozac does however inhibit certain drugs at a clinical level at 2D6, which does not affect common benzodiazepines.
Luvox, fluvoxamine, however, is known to affect 3A4, which affects the level of alprazolam and diazepam (Xanax, Valium).
-- Jay
This is the end of the thread.
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