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provigil+-alpha/beta blocker? ed_uk

Posted by mike99 on March 4, 2006, at 19:24:26

In reply to Re: Coreg (carvedilol) mike99, posted by ed_uk on March 4, 2006, at 18:05:17

> Hi Mike :)
> I doubt you'll need an alpha/beta blocker with Provigil but I suppose it's possible. If you do, you might respond well to atenolol alone, without an alpha blocker.
> Kind regards
> Ed

Thanks Ed. I always appreciate your input, it is extremely helpful.

The reason I'm concerned about only using a beta blocker w/Provigil is that I've read in the physicians desk reference that beta blockers "increase pressor effects of sympathomimetics"-- and also a previous thread by rphstudent cautioned that combining a sympathomimetic and beta blocker can lead to a dangerous phenomenon called "unopposed beta blockade"--where beta receptors are blocked out of proportion with alpha receptors.

For example, based on this premise I believe the protocol for cocaine/amphetamine toxicity in the ER is to never give a beta blocker alone but a mixed alpha/beta antagonist. Perhaps I don't understand this fully, it is more theoretical than practical or only applies to severe acute toxicity because several babblers claim to use beta blockers alone with stimulants/sympathomimetics.

Also, I realize Provigil is not technically a sympathomimetic but it definitely does have sympathomimetic properties (don't know if you caught this in a recent thread under "provigil discussion") and that I might tolerate it without any cardiac meds. However, despite my good health, my physiology is such that I'm probably one of the small minority that would be extremely sensitive to provigil from a cardiovascular standpoint.

I've read of 2 babblers having to go to the ER due to the cardiovascular effects of provigil. Been there, done that (w/ amphetamine), got the t-shirt, don't want to visit again ;) That's why I'm being so cautious and meticulous in my research (and of course always proceed under physician supervision).

Might you have any thoughts on this? And are you aware if atenolol has any benefits (or drawbacks) compared to say toprol?



Thanks Ed. Do you know if atenolol has any advantages over toprol?




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