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divided doses » Declan

Posted by pseudoname on November 28, 2005, at 9:50:51

In reply to Re: discouraged—bupe DAY 10, posted by Declan on November 27, 2005, at 20:08:48

Hey, Declan.

> Why do you take bupe in divided doses throughout the day?

This is a good question. My only reason was that other people said they did. Elizabeth took it 3 times a day. (And she had to lie on the floor and drip it into her nose.) A few others in the archives also. And the only 2 papers on bupe-for-depression used divided doses. Supposedly for addiction, bupe's effect is long-lasting; as an antidepressant, it wears off within 6 hours. I hadn't questioned it.

But this morning I took 1.8 mg, my highest dose yet, and I took it all at once. (Actually, I divided it over 2 hours just to make sure I wouldn't puke.) It kicked in. I had forgotten what bupe's relief felt like last week when I first went up to 0.6 mg.

But will it last??

> ...a small nice feeling for 2 hours a day. Or would you be glad to have even that?

I'll take what I can get, even 2 hours – if they could be reliable. This morning I've had 4 hours so far. I've decided that when it starts to wear off, I'll hit it again with about 0.5 mg and hope that my problem isn't rapid tolerance but just that I need a high dose. No one else has reported needing to take so much to get a response so soon after beginning with buprenorphine. I mean no one who was opioid-naive when starting treatment: former users go way higher (16 mg).

There's just not enough published experience with it. Maybe the fact that bupe only worked with about 50% of TRD people in those studies is that they didn't try enough right away.

You gotta do what you gotta do.




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