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discouraged—bupe DAY 10

Posted by pseudoname on November 27, 2005, at 17:36:57

In reply to Re: buprenorphine trial !, posted by Peter S. on November 17, 2005, at 1:22:04

At this point, I have no buprenorphine benefits to report.

       Day   6: 0.6 mg total, in divided doses
       Day   7: 0.6
       Day   8: 1.0
       Day   9: 1.0
       Day 10: 1.4

On Day 6 in the evening, my diary says "I feel unusually good," and situations seemed manageable that would typically freak me out. But on Day 7 (Thanksgiving) & later, I was depressed & stressed as usual, and despite dose increases I now see no cognitive or mood benefit at all.

In all journal & Web reports of bupe-for-depression, it works quickly (0-3 days) if it works at all. Callaway said "most patients experience benefits of an adequate dose within three hours" !! So "an adequate dose" is the real question. The thing is, most of the responders got at least *some* benefit with lower doses than I'm already taking even if they needed higher doses for complete benefit. So I'm not hopeful. But I'll go to 3 mg/day for 3 days before giving up.

When I first take an increased dose and feel slightly dizzy, I also have some minor happy-feelings. But I'm disregarding those as non-therapeutic and part of the dizziness; they're like the brief mood-lift alcohol initially gives me. If they persisted that'd be great, but they don't even last as long as the dizziness.

Side effects: headaches come & go; mild itchiness; splotchy rash on my face. Constipation may be a problem. I haven't had to poop since yesterday morning, when it was pretty hard.




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