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Re: DPSP database clomipramine dopamine affinity

Posted by linkadge on November 1, 2005, at 21:28:09

In reply to Re: DPSP database clomipramine dopamine affinity » linkadge, posted by zeugma on November 1, 2005, at 19:47:29

>anticholinergic effects can impair memory, but I >seriously, seriously doubt that memory >impairment is the mechanism by which they may >contribute to alleviation of depressive states.

THe TCA's are arguably more effective for certain depressive states than newer drugs, even say, effexor, which shares the TCA's dual uptake inhibiting properties. The main difference are the anticholinergic side effects. Anticholinergics are oftentimes euphoriants. I personally find anticholinergics very mood brightening. I found cogentin was an antidepressant.

I personally do not doubt that impairment of certain aspects of memory can have antidepressant effects, so as to agree with Breggin's theory of "Brain Disabling Treatments", essentially where many "theraputic responses" in psychiatry correspond directly to impairment of some aspect of neurological functioning. What do ECT and TCA's have in common besides their higher efficacy in depression? Memory impairment, among other dirty consequences.

Linkadge



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URL: http://www.dr-bob.org/babble/20051031/msgs/574335.html