Posted by SLS on March 25, 2005, at 13:13:54
In reply to Re: What is going on? » Larry Hoover, posted by Maxime on March 25, 2005, at 12:18:10
Hi.
I wouldn't recommend using imipramine in combination with an MAOI. It is serotinergic and can produce a mild to moderate SS, especially if combined with Nardil.
- Scott
> I am not saying it's not causing the problem, but it can and has been done(see below). I was taking Surmontil for a while with Parnate no problem. Others on the board have as well.
>
> My reaction seemed to be more hypertensive than "serotonin syndrome" in nature.
>
> I think I am dying. That's what it feels like. Or maybe it is because my desire to die is so strong that I feel this way.
>
> I've been crying for two hours straight. I can't stop. I'm trying to keep away from my "sharps".
>
> My doctor is useless.
>
> M.
>
>
>
> J Clin Psychiatry. 1985 Jun;46(6):206-9.
>
> Combined MAOI, TCA, and direct stimulant therapy of treatment-resistant depression.
>
> Feighner JP, Herbstein J, Damlouji N.
>
> Patients with "treatment resistant" depression who do not respond to standard methods or relapse over time have a moral and legitimate right to innovative
> therapy. Combined treatment with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), and stimulants has been resisted by practitioners because of hypertensive and hyperthermic crises noted in certain cases. This paper reports a case series demonstrating the safety and efficacy of adding a stimulant to an MAOI or to a combination of TCA and MAOI in the treatment of intractable depression.
>
> PMID: 3997787 [PubMed - indexed for MEDLINE]
>
>
>
> > > I have been taking 25 mg of Desipramine at night.
> >
> > You are taking that with the Parnate?
> >
> > That may well be the problem, right there. Your symptoms seem to be due to serotonin syndrome, although not serious in an absolute sense.
> >
> > You can't take desipramine with Parnate.
> > http://www.rxlist.com/cgi/generic2/tranylcypromine_od.htm
> >
> > It is specifically listed as forbidden.
> >
> > Lar
>
>
poster:SLS
thread:475253
URL: http://www.dr-bob.org/babble/20050322/msgs/475428.html