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Re: What is going on? Larry Hoover

Posted by SLS on March 25, 2005, at 12:09:00

In reply to Re: What is going on? Maxime, posted by Larry Hoover on March 25, 2005, at 10:42:09

> > I have been taking 25 mg of Desipramine at night.
> You are taking that with the Parnate?
> That may well be the problem, right there. Your symptoms seem to be due to serotonin syndrome, although not serious in an absolute sense.
> You can't take desipramine with Parnate.
> It is specifically listed as forbidden.
> Lar

Serotonin syndrome was my first inclination. That's why I asked about whether or not trazodone was being used as a sleep aid.

You can mix Parnate + desipramine without sequalae. I've done it. Desipramine is a very selective if not specific NE reuptake inhibitor and should be devoid of 5-HT potentiation. I am not aware of any other properties of desipramine that would make it theoretically dangerous.

The only thing that ever got me well was a combination of Parnate 60mg + desipramine 150mg. I am currently taking Parnate 80mg + nortriptyline 100mg. I had once taken Parnate 150mg + desipramine 300mg. I am not so unusual in my tolerance of this combination. It is safe.

- Scott




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