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Re: What is going on? Larry Hoover

Posted by Maxime on March 25, 2005, at 12:18:10

In reply to Re: What is going on? Maxime, posted by Larry Hoover on March 25, 2005, at 10:42:09

Hi Larry,

I am not saying it's not causing the problem, but it can and has been done(see below). I was taking Surmontil for a while with Parnate no problem. Others on the board have as well.

My reaction seemed to be more hypertensive than "serotonin syndrome" in nature.

I think I am dying. That's what it feels like. Or maybe it is because my desire to die is so strong that I feel this way.

I've been crying for two hours straight. I can't stop. I'm trying to keep away from my "sharps".

My doctor is useless.


J Clin Psychiatry. 1985 Jun;46(6):206-9.

Combined MAOI, TCA, and direct stimulant therapy of treatment-resistant depression.

Feighner JP, Herbstein J, Damlouji N.

Patients with "treatment resistant" depression who do not respond to standard methods or relapse over time have a moral and legitimate right to innovative
therapy. Combined treatment with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), and stimulants has been resisted by practitioners because of hypertensive and hyperthermic crises noted in certain cases. This paper reports a case series demonstrating the safety and efficacy of adding a stimulant to an MAOI or to a combination of TCA and MAOI in the treatment of intractable depression.

PMID: 3997787 [PubMed - indexed for MEDLINE]

> > I have been taking 25 mg of Desipramine at night.
> You are taking that with the Parnate?
> That may well be the problem, right there. Your symptoms seem to be due to serotonin syndrome, although not serious in an absolute sense.
> You can't take desipramine with Parnate.
> It is specifically listed as forbidden.
> Lar




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