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Re: Cymbalta TCAs mixed states ed_uk

Posted by barbaracat on March 24, 2005, at 19:39:43

In reply to Re: Cymbalta TCAs mixed states barbaracat, posted by ed_uk on March 24, 2005, at 18:23:00

> I only lasted one day on amitriptyline. I was almost unconscious for 24 hours- couldn't keep my eyes open!!
> >Elavil, Tofranil. I HATED the side effects.
> What side effects did you have?

**Same as you - walking around unconscious and with strange stiffness in my fingers and peripheral skeletal muscles. Couldn't pee.
> >
> It's strange how pdocs sometimes say that TCAs are more likely to induce mania than SSRIs and yet patients often find the opposite.

**Yes, that seems unfortunate.
> >About 2-1/2 years ago....
> I'm surprised your pdocs didn't spot it earlier- it sounds like you've had some quite 'classic' manias as well as the mixed states and depressions.
**I don't think mixed states are an easy marker for a dx of bipolar, but certainly, something else was obviously going on with me than just depression. My mixed states depressions were so severe and psychotic I don't think my docs knew what to do with me. Antipsychotics were tried but didn't help. I strongly resisted the label 'bipolar' and bipolars can be pretty persuasive, don't keep appointments when they're flying high. But to be honest, I think pdocs miss the obvious far too often and a really good one is a rare thing.

**BTW, what kinds of MAOIs are you considering, Ed? I hear good things about Nardil.




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