Posted by chemist on January 13, 2005, at 0:21:49
In reply to Re: Methamphetamine vs N-acetyl-l-cysteine » JayDee, posted by Larry Hoover on January 11, 2005, at 18:30:36
> > Larry, thanks for the reply.
> >
> > But that doesn't explain why NAC reduceses the effects of MAP (in this case, acute hyperlocomotion)
> > Hyperlocomotion couldn't possibly be a result of oxidative stress could it??
> >
> > The abstract also doesnt explain behaverial sensitzation other then that NAC attenuates MAP induced dopmaine deficits.
>
> I'll take a look at this again, but I can't right now. I'll also check related research. I attributed the adverse effects of the methamphetamine to oxidized dopamine, which destroys any dopamine-binding element (receptor, reuptake transporter, etc.). I could certainly be wrong about that. More, anon.
>
> Lar
>
hello all, chemist here...might i join? the pubs i have on hand - from 1982 through 2004 - indicate that the neurotoxicity (this word is to be used with care, especially in re: the work of ricaurte and mccann, to name the most obvious contenders) of MA in re: both DA and 5-HT receptors appears to be axonal in nature...also, a bit of a chicken-and-egg problem, as the oxidation of DA is likely (specifically) a result of decreased (endplate locus) expression of tyrosine hydroxylase...on the radar recently (1995-current) is the role of monoamine vesicular transporter (type II), which sequesters DA from oxidative mechanisms...i have one pub (Ann. N.Y. Acad. Sci., 1025:146-150, 2004) on hand wherein this mechanism is addressed in re: MA specifically; and there is a freebie (JPET, 311:1-7, 2004) wherein microglia activation is fingered as the cause of DA receptor damage. i will state that mccann and ricaurte's review (Neuro. Bio. Rev., 27:821-826, 2004) is rather unbiased and the refs therein are a broad sampling from the literature. i was impressed with the MPTP challenge for rats dosed with MA, either with prior methylphenidate administration or with subsequent treatment...the methylphenidate staves off MPTP DA trouble if used prophylactically, and is somewhat of a restorative agent if used later....hope this sheds some light..all the best, chemist
poster:chemist
thread:439943
URL: http://www.dr-bob.org/babble/20050108/msgs/441458.html