Posted by Larry Hoover on January 11, 2005, at 11:04:18
In reply to Methamphetamine vs N-acetyl-l-cysteine, posted by JayDee on January 9, 2005, at 22:32:37
> Can someome help me interprate these abstracts?
> My interpretation:
>
> 1.)N-acetyl-l-cysteine prevents sensitization and neurotoxicity by blocking the effects of Methamphetamine rather then just reducting oxidative stress.Methamphetamine causes massive release of dopamine from storage sites in presynaptic neurons. The flood of dopamine overwhelms the capacity of enzymes which normally detoxify dopamine that escapes the reuptake pumps. Dopamine is readily oxidizable to quinone and semiquinone derivatives, which are toxic. Oxidation is inhibited by glutathione, so NAC boosts the protective ability of natural antioxidant capacity, reducing oxidative damage via dopamine derivatives.
> Why does N-acetyl-l-cysteine do this?
By directly increasing formation of glutathione. If you increase substrate concentration, you increase products. It's that simple.
> anyone with personal experience with this?
>
> What is the duration of a N-acetyl-l-cysteine dose?That I don't know. But, in any case, having lots of glutathione available is a good thing.
Lar
poster:Larry Hoover
thread:439943
URL: http://www.dr-bob.org/babble/20050108/msgs/440625.html