Posted by Larry Hoover on January 11, 2005, at 18:30:36
In reply to Re: Methamphetamine vs N-acetyl-l-cysteine, posted by JayDee on January 11, 2005, at 16:10:33
> Larry, thanks for the reply.
>
> But that doesn't explain why NAC reduceses the effects of MAP (in this case, acute hyperlocomotion)
> Hyperlocomotion couldn't possibly be a result of oxidative stress could it??
>
> The abstract also doesnt explain behaverial sensitzation other then that NAC attenuates MAP induced dopmaine deficits.I'll take a look at this again, but I can't right now. I'll also check related research. I attributed the adverse effects of the methamphetamine to oxidized dopamine, which destroys any dopamine-binding element (receptor, reuptake transporter, etc.). I could certainly be wrong about that. More, anon.
Lar
poster:Larry Hoover
thread:439943
URL: http://www.dr-bob.org/babble/20050108/msgs/440794.html