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Re: Cymbalta (duloxetine) - report pseudonym

Posted by SLS on September 4, 2004, at 11:18:05

In reply to Re: Cymbalta (duloxetine) - report SLS, posted by pseudonym on September 4, 2004, at 10:40:05

Hi Pseudonym.

> My interest is in Cymbalta, and I would like to know if you can actually distinguish between the effects of all four substances in the CNS (see below). On the surface, it would seem difficult to ascribe benefits/effects to one or the other.

> You mentioned that your regimen included Abilify, Lamictal, Namenda, now in addition to Cymbalta. With this combination, you are affecting many neurotransmitters/receptors, including serotonin, noradrenaline, dopamine, glutamate, and NMDA.

Wow. I'm going to have to think about that one for awhile. I probably could only identify what is doing what by removing them one at a time. Because I have been on and off these things a few times, I could probably guess which one was removed, but I don't think I could verbalize now the things I would experience in advance.

Abilify gives me more motivation and reduces anxiety and adds some socialability.

Lamictal gives me more physical energy and interest in things and reduces depression somewhat. When the dosage isn't too high, it promotes better concentration.

Namenda is difficult for me to assess right now. It initially produced significant improvements in depression and cognition. Right now, it might not be doing anything at all, but I am leaving it on board in case it provides an augmentative effect.

When Cymbalta began to do something a few days ago, it was a broad-spectrum antidepressant effect that affected most all symptoms.


- Scott

 

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