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Re: Cymbalta (duloxetine) - report theo

Posted by 4WD on September 5, 2004, at 18:22:57

In reply to Re: Cymbalta (duloxetine) - report, posted by theo on September 5, 2004, at 17:27:37

> I hear a lot of people saying Effexor helped them with motivation and for me, it made me more emotionally flat and numb to where it didn't give a darn about the 2 feet of paper work stacking up on my desk.
> Is norepinephrine really the "key" to motivation?

Effexor made me emotionally flat as well. No motivation, lots of apathy. No joy in anything. I don't know if the Effexor actually *caused* all that but it sure didn't take it away.

Everyone seems to agree, however, that Effexor doesn't have a norepinephrine effect at low doses. I was only taking 37.5 mg/day because of side effects so it would only have been affecting serotonin. Part of what I don't understand about this, though, is that I didn't get the SSRI side effects with Effexor that I did with Zoloft, Prozac, Celexa or Lexapro so it must have been doing *something* besides serotonin reuptake inhibition.

Anyway, I'm now on Cymbalta which I'm hoping to be able to take therapeutic dosage and then we'll see if norepinephrine has a motivational, anti-anhedonia effect.

What's your dosage of Effexor? Is it a low one? I keep thinking the thing to do is add some dopamine stimulation.





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