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Cymbalta (duloxetine) - report

Posted by SLS on August 21, 2004, at 8:13:25

Cymbalta (duloxetine)


I began to taper my dosage of imipramine from 300mg



I took my last 50mg dose of imipramine

I am experiencing a mild rebound improvement of depression that is the direct result of discontinuing imipramine so quickly. This is normal for me.



Begin Cymbalta...

First dose - 30mg

I experienced a brief significant improvement in depressive symptoms beginning 1 hour after this first dose. It lasted for 3 hours. No side effects.



Second dose - 30mg

I did not experience any improvement. No side effects.


* The manufacturer's label describes initiating treatment with Cymbalta using the desired target dosage. People are to begin by taking 40-60mg per day. Dosing is probably best split as twice a day. The half-life of Cymbalta is approximately 12 hours.

* My doctor asked that I take 30mg for the first week before moving up to 60mg in the second week. I am impatient, of course, but this is probably prudent, especially after having so recently discontinued imipramine.

* Smiling

- Scott




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