Posted by SLS on August 16, 2004, at 23:13:58
In reply to Re: TRICYCLICS: Is there a best one? » SLS, posted by zeugma on August 16, 2004, at 19:41:43
Hi Z.
> Was it that side effects made it impossible to tolerate the dosage, or that suddenly the dosage would lose effect?
I suddenly lose the effect. One day I would take 75mg and lose the antidepressant effect. The next day I would take 100mg and regain the effect for a portion of the day, and then lose it. I would not regain it until I dropped back down to 75mg, and then only for a portion of the day. It was like I would get an antidepressant effect on the way up and on the way down, but nothing in the middle.
> Also, if you'd care to speculate, why do you think nortriptyline is alone among the TCA's in having a curvilinear response window?
That is a great question that I always thought might hold a clue as to why these drugs work at all. Nortriptyline might offer a unique look into what's going on. Maybe Panda can come up with a theory. It's things like this that have me question the necessity for neurogenesis to occur before experiencing an improvement of depression.
> Are the upper limits for imipramine etc. set at 300 mg simply because that's where the s/e burden gets too steep?
Yes. For extensive metabolizers, sometimes dosages above 300mg are necessary.
- Scott
poster:SLS
thread:378159
URL: http://www.dr-bob.org/babble/20040811/msgs/378448.html