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Re: TRICYCLICS: Is there a best one? SLS

Posted by zeugma on August 16, 2004, at 19:41:43

In reply to Re: TRICYCLICS: Is there a best one?, posted by SLS on August 16, 2004, at 8:45:02


I agree with you about the importance of dosing nortriptyline properly. 100 mg nortriptyline is giving me a much more robust response than 75 mg. It seems odd, though, that you would be able to tolerate 300 mg imipramine, but not be able to find a stable window for nortriptyline- i remember you mentioned that your doctor found that relatively common. Was it that side effects made it impossible to tolerate the dosage, or that suddenly the dosage would lose effect?

Also, if you'd care to speculate, why do you think nortriptyline is alone among the TCA's in having a curvilinear response window? Are the upper limits for imipramine etc. set at 300 mg simply because that's where the s/e burden gets too steep?





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