Posted by elleff on October 19, 2003, at 19:16:46
In reply to Sublingual Selegiline - more qs - more effective?, posted by btnd on October 17, 2003, at 7:47:33
> Why do you care about special sublingual brand of selegiline? Can't someone just crush Jumex/Deprenyl/Segan (selegiline 5mg) pills to powder and put them under the tongue?
In my experience putting one tablet under the tongue and allowing it to disolve and absorb is quite effective if you can stand the bitter taste.
> Does anyone know if using selegiline sublingually would be more effective or have less side-effects?
I don't think there is any concrete evidence here, but my guess is that because selegiline has such a short half-life (less than 30 mins) and a high rate of first pass metabolism (into desmethyl selegiline and l-methamphetamine), the SL route simply puts more of the parent compound into your brain. As 2.5 - 5mg per day of selegiline will completely inhibit MAOI-B, one 5mg tablet per day SL should be all that is required, which conforms with my experience.
The clinical trial data suggests that 30-60mg of oral selegiline, or 20mg per day of transcutaneous selegiline is an effective antidepressant dose (the patch is soon likely to get FDA approval). At the above oral dose selegiline is nonselective and is quite similar to tranylcypramine (Parnate).
Other trial data suggests that 10mg per day of Selegiline plus 250mg - 1,000mg per day of DL-phenylalanine is an effective antidepressant combination.
My experiences is that 5mg of Selegiline SL in the morning, plus 500mg DL-phenylalanine + 200mcg of Chromium chelate + a Vit B6 & Vit C containing multivitamin morning and afternoon is pretty effective for ADD and dysthymic symptoms. The chromium probably works via an insulin augmenting action which increases transport of branch-chain and aromatic amino acids across the blood brain barrier. Presumably the combination increases the amount of endogenous PEA (phenylethylamine) quite substantially and probably also increases dopamine levels. PEA is only one methyl group short of dexamphetamine, which presumably works as a high-powered exogenous version of the former.
For best absorption and BBB penetration DL-phenylalanine should be taken on an empty stomach.
regards
elleff
poster:elleff
thread:208454
URL: http://www.dr-bob.org/babble/20031015/msgs/270927.html