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Re: Attn hok: Sublingual Selegiline Trial Results? Ron Hill

Posted by hok on March 13, 2003, at 13:31:37

In reply to Attn hok: Sublingual Selegiline Trial Results?, posted by Ron Hill on March 12, 2003, at 13:23:48


Sory to hear about your recent trouble with NADH. I had experienced the same tolerance and irritability effects you speak of. It's too bad the initial effects couldn't be kept up.

Yes, the selegiline is still working. I take anywhere from 1-3mg of it per day (usually all together in 1 dose in the AM). It is completely different from the NADH, even though both seem to affect a modulation of tyrosine hydroxylase. The main effect of the selegiline is probably the MAO-B inihibition - something that has helped replace the smokes for now. At the same time, there is no tiredness, irritability, or rebound effect like I experienced on the NADH. It is not as energizing as the NADH (but I keep the dosage low as well). Yet the anti-anhedonic effect seems to be fairly equivalent. I'm convinced selegiline is definitely one of those drugs that you see a very diverse response to. You just don't know how you're going to react to it until you try it.
Initially, I tried 5-10mg per day + DLPA or tyrosine, but once the full effects kicked in, the dose proved to be way too high and I eventually cut out the DLPA/tyrosine altogether. Too much of the selegiline can induce anxiety /tension. I think this is because of the increase of PEA.

I'm convinced there is a fairly big difference between the sublingual version and the oral tablets. The sublingual version acts much quicker, and more importantly, reduces the amount of metabolites which are responsible for all of the bad side effects.

Due to long-standing sleep disruption issues [not associated with the selegiline], I've very recently added remeron to my regimen. I'm unclear what effect this will have on the selegiline, but I'm hoping, if anything, it will increase its effects since remeron's 5HT2A antagonism increases dopaminergic activity.

If you have any specific questions I didn't answer, please let me know.





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