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Sublingual Selegiline - more questions hok

Posted by not exactly on March 15, 2003, at 21:20:48

In reply to Re: Attn hok: Sublingual Selegiline Trial Results? Ron Hill, posted by hok on March 13, 2003, at 13:31:37

> I'm convinced there is a fairly big difference between the sublingual version and the oral tablets. The sublingual version acts much quicker, and more importantly, reduces the amount of metabolites which are responsible for all of the bad side effects.

I've tried selegiline in both patch form (worked very well for me) and oral (mixed results). I'm intrigued by the concept of sublingual administration, but I haven't tried it yet. Could you get the same sublingual effect by placing a standard oral tablet (or part of one) under the tongue? How about powder from opening a selegiline cap?

Also, it would seem that regardless of the physical form (liquid, tablet, powder), only some of the medication would be absorbed directly thru the mouth. Doesn't the rest eventually get swallowed and thereby result in the same first-pass metabolism byproducts? Or do you spit it out instead? How long do you leave it under your tongue?

- Bob


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