Posted by dr dave on October 2, 2002, at 12:28:44
In reply to Re: s-citalopram and r-citalopram, posted by JLM on October 1, 2002, at 5:51:57
There's a good article about stereoisomeric drugs at
http://pubs.acs.org/cen/coverstory/7940/7940chiral.htmlIt seems likely there will be more and more single enantiomers. This will either be a fantastic thing or a terrible thing, depending on the particular drug. Developing single enantiomers has huge potential to separate side-effects off from beneficial effects, which is fantastic. It can also be used to 'extend drug life cycles', which means taking more than your fair number of years' profits from a given drug.
The important thing is to keep informed and work out which is which.
> Dr. Dave, I was doing some surfing tonight and came across some studies/info about the non-racemic version of Fluoxetine, r-fluoxetine. Apparently before research on the compound was stopped due to the danger of prolonged QT intervals, they were making the same claim that Forrest is making about s-citalopram, namely less side effects from the non-racemic mixture.
>
> Is this going to be the new trend? Was there any actual evidence that r-fluoxetine caused less side effects? It makes one wonder, how many other stereoisomer drugs we are going to see with claims off less SE's, especially in the area of psychiatric drugs.
>
>
>
poster:dr dave
thread:121478
URL: http://www.dr-bob.org/babble/20020930/msgs/121962.html