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Re: s-citalopram and r-citalopram

Posted by JLM on October 1, 2002, at 4:48:16

In reply to s-citalopram and r-citalopram » JLM, posted by dr. dave on October 1, 2002, at 3:47:51

> There is a lot of evidence on this sort of thing at http://www.cipralex.ch/f/poster.html
>
> The study
> http://www.cipralex.ch/pdf/poster/sobp_500.pdf
> in particular demonstrates that s-citalopram is almost entirely responsible for the SSRI activity of citalopram.
>
> In terms of evidence for r-citalopram causing side-effects - there just isn't any. An interesting thing to look at is the bit at the botttom of
> http://www.cipralex.ch/pdf/poster/ifmad_01.pdf
> where it says 'Escitalopram has demonstrated a lack of affinity for a very large number of receptors and binding sites - measured as citalopram'. This is followed by a list of over 50 receptors. What this shows is that this lack of activity must also be true of r-citalopram, because the results are for s- and r-citalopram combined.
>
> I keep on asking for any evidence that r-citalopram causes side-effects and no-one can come up with anything - but it gets repeated as a known fact. What can you do?
>
>
> > > Where is the evidence that the s-isomer is the one that causes the so called AD effect, and that the r-isomer causes SE's? I have yet to see anyone present that here. Forrest certainly cannot back that claim up with hard data.
> >
> >
>
>

Dr. Dave thanks for that info, I will take a look at that. Very useful.


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URL: http://www.dr-bob.org/babble/20020930/msgs/121772.html