Posted by dr. dave on October 1, 2002, at 3:47:51
In reply to Re: Lexapro Dosage (vs. Celexa) « yeltom, posted by JLM on September 30, 2002, at 5:40:22
There is a lot of evidence on this sort of thing at http://www.cipralex.ch/f/poster.html
The study
http://www.cipralex.ch/pdf/poster/sobp_500.pdf
in particular demonstrates that s-citalopram is almost entirely responsible for the SSRI activity of citalopram.In terms of evidence for r-citalopram causing side-effects - there just isn't any. An interesting thing to look at is the bit at the botttom of
http://www.cipralex.ch/pdf/poster/ifmad_01.pdf
where it says 'Escitalopram has demonstrated a lack of affinity for a very large number of receptors and binding sites - measured as citalopram'. This is followed by a list of over 50 receptors. What this shows is that this lack of activity must also be true of r-citalopram, because the results are for s- and r-citalopram combined.I keep on asking for any evidence that r-citalopram causes side-effects and no-one can come up with anything - but it gets repeated as a known fact. What can you do?
> > Where is the evidence that the s-isomer is the one that causes the so called AD effect, and that the r-isomer causes SE's? I have yet to see anyone present that here. Forrest certainly cannot back that claim up with hard data.
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poster:dr. dave
thread:121478
URL: http://www.dr-bob.org/babble/20020930/msgs/121768.html