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dopamine drugs or supplements

Posted by andys on September 16, 2001, at 12:51:57

I had some questions on dopamine therapy:

1-I have had a remarkable response (both anti-depressant and mood stabilization) to the dopaminergic drugs phentermine and mirapex, but can’t tolerate the side effects (which is common for me, on any psych meds). As an alternative to prescription meds, has anyone had experience with the supplement NADH (coenzyme #1), which is supposed to raise dopamine levels?

2- I’d like to switch from seroquel (a dopamine antagonist) to amilsupride (a dopamine agonist), but my pdoc favors ziprasidone for a switch (I use seroquel for sleep, and mood stabilizer, I am untra-rapid-cycling bipolar). I found a chart that the two have equivalent D2 agonist action, but no mention of D3. Also, is amisulpride supposed to help sleep?

3-He also claims that mirapex is primarily a serotonin 5ht agonist, and dopamine is secondary, which I can find no research to support his supposition, any thoughts? (I need to resolve, to support my argument that it’s dopamine I respond to, and need to pursue in the future).

4-A Parkinson’s site says that although D2 helps the Parkinson’s symptoms, it’s the D3 that is responsible for the anti-depressant and mood elevating properties, and therefore, I should focus mostly on the D3 agonist drugs. Any thoughts on this, and which drugs have the most potent D3 agonist? By the way, there’s an interesting chart on dopamine agonists of different drugs at:





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