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Re: grouch's rebound effect SLS

Posted by Grouch on October 1, 2001, at 20:42:10

In reply to Re: grouch's rebound effect, posted by SLS on October 1, 2001, at 8:06:43


> Hi.
>
> The withdrawal rebound is most likely being produced by physiological processes in the brain that cause a shift in neural function in the direction of improvement. It might have something to do with the changes in receptor numbers or function that result from chronic exposure to the drug persisting for a few weeks after the drug is withdrawn. I am sure that it is not an illusion or unmasking due to the waning of side effects. It can be thought of as an "unspringing" of a coil spring resulting from the removal (withdrawal) of the physiological "weight" of the drug that had been compressing it. The spring ends up reaching a height greater than its initial ground state (baseline).
>
>
> - Scott


Hi Scott & Andy. I agree w/Scott on this one that improvements during withdrawal are more likely due to re-regulation of receptors rather than "brain/blood levels" or unmasking of side effects.


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