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Re: modafinil

Posted by per ekstrom on November 12, 2001, at 3:42:53

In reply to Re: modafinil SalArmy4me, posted by Jane D on September 17, 2001, at 17:18:07

Modafinil has an indirect but likewise very important effect on dopamine. Its via glutaminergic mechanism that inhibits GABA release which in turn enhance dopaminergic activity.


> > Modafinil does not work on dopamine at all: http://www.rxlist.com/cgi/generic2/modafinil_cp.htm It is useless in depression unless one has trouble with drowsiness.
>
> Sal,
> Could you elaborate. Do you mean Modafinil was useless for you? That it is useless for most people? That it has not been studied yet for this indication? I'm sure you don't mean that it will not work for anyone since that is something you can't possibly know.
>
> I looked at the web site you referred to and I wasn't sure that it really said this didn't affect dopamine at all. Also, while it was very interesting to read, I didn't see any author's name on that entry. I admit I didn't search the entire site. Do you know where I could find that information?
>
> Finally I do know of one reference to Modafinil and depression. Check out
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10847314&dopt=Abstract
> for a description of Modafinil as an augmenter. Personally, I don't take a case series of 7 all that seriously but you have listed similar articles many times in the past so I assume that you do think that these reports are important.
> -Jane


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poster:per ekstrom thread:78856
URL: http://www.dr-bob.org/babble/20011104/msgs/83953.html