Posted by Grouch on September 16, 2001, at 22:38:45
In reply to dopamine drugs or supplements, posted by andys on September 16, 2001, at 12:51:57
> 2- I’d like to switch from seroquel (a dopamine antagonist) to amilsupride (a dopamine agonist),Hi Andy. Amisulpride is actually a D2/D3 antagonist (not agonist), but it works differently than seroquel and ziprasidone. While the latter block postsynaptic receptors, low doses of amisulpride block the presynaptic D2/D3 receptors which causes an increase of dopamine in the synapse. The generally results in an antidepressant effect (perhaps comparable to what you experience with Mirapex) rather than an antipsychotic or tranquilizing effect.
At high doses, amisulpride blocks post-synaptic D2/D3 receptors which results in an antipsychotic or tranquilizing effect (perhaps comparable to what you expereience with Seroquel).
>I found a chart that the two have equivalent D2 agonist action, but no mention of D3.
Interesting chart, though again, it is comparing the D2 antagonist (not agonist) actions of the different drugs.
> Also, is amisulpride supposed to help sleep?
Not usually at the low doses you would want to use it at.
> 3-He also claims that mirapex is primarily a serotonin 5ht agonist, and dopamine is secondary, which I can find no research to support his supposition, any thoughts?
I have never heard anything about Mirapex directly affecting 5HT. I would ask him where he got this information!
>(I need to resolve, to support my argument that it’s dopamine I respond to, and need to pursue in the future).
Yes, too many psychiatrists seem to think all depression revolves around serotonin. But my own experience, and what I've read from others on this board suggests that in many cases dopamine plays a critical role. Good luck.
poster:Grouch
thread:78856
URL: http://www.dr-bob.org/babble/20010907/msgs/78889.html