Posted by AndrewB on July 4, 2000, at 20:12:36
In reply to Re: Adrafinil? Sulpiride? » SLS, posted by KarenB on July 4, 2000, at 12:40:20
Scott,
Thanks for the info. below on Adrafinil. I think it is important to know to try to understand its underlying mechanism(s) of action. There was mention that modafinil might act, at least in part, via increased glutamate levels and decreased GABA in areas of the brain involved with sleep wakefulness. My experience with the amino acid l-glutamate is that it is very arousing. Possibly adrafinil acts on glutaminergic transmission or indirectly on NE....idle speculation.
I have never used less than 50mg. of amisulpride a day. No studies have used less than 50mg/day.
Sulpiride doses, from the literature I’ve read, can range from 100mg to 400mg. per day. The average therapeutic dose may fall between 150 and 200mg per day. Dosing varies possibly due to individual variation in the absorption of Sulpiride. It is not clear whether multiple daily dosing is preferable over once daily dosing.
Yes I’m thinking initial somnolence and sedation is an indicator of non-response with amisulpride. Maybe what is happenning is that postsynaptic receptor (instead of presynaptic receptor) antagonism is occurring even at low doses. Why??? The individual maybe has lessened presynapatic receptor binding affinities? A lower number of presynaptic receptors? All I can say is it is very curious.
Thanks for the info. about the consultant saying greater binding affinities may hobble the effectiveness of amisulpride. Could you ask what the implications of this may be for those who take amisulpride; 1) more non-responders vs. Sulpiride 2) a less robust effect 3) a greater chance of postsynaptic instead of presynaptic antagonism at low doses.
I’m not that disappointed by recent drug trial failures. I am very grateful for how I feel now though I’m still seeking additional improvement. I recently stopped
St. John’s Wort because it seems its serotonin action was making me lethargic, sleepy, groggy and less mentally sharp. No serotonin enhancement for me I guess.I increased my dose of reboxetine to 12mg/day, the maximum dose, due to partial poop out. Good arousal has been restored I believe.
After trying neurontin for about a month, I don’t think I have a use for it. Makes me a little sleepy and relaxed, that is about it.
Am trying seligiline at 5mg/day for social anxiety. Supposedly need 4-6 weeks to take effect.
Happy 4th!!!
AndrewB
poster:AndrewB
thread:39176
URL: http://www.dr-bob.org/babble/20000630/msgs/39380.html