Posted by SLS on July 4, 2000, at 11:14:27
In reply to Re: Sulpirde-SLS, posted by AndrewB on July 4, 2000, at 10:29:35
> Scott,
>
> Could you ask your doctor when you see him if he purposely is starting you out at a less than therapuetic dose and why? I find this curious. Maybe this primes the presynaptic receptor and the dose will be increased with your next visit?
>
> Some info on Sulpiride and mood stabilization on the Solian Philippines website. My experience with amisulpride is less moodiness and irritability.
>
> Thanks for keeping us updated on your sulpiride experience.
>
> I have stopped my trial with sinemet (with l-dopa) and entacapone. Causes a lowering of the mood, increased social anxiety and little if any increased arousal. Literature for use of amisulpride for dysthymia says l-dopa interferes with action of amisulpride.
>
> AndrewB
Hey Andrew! You're back!As far as to why my doctor started me out with such a low dose, I'm not sure. I know that his consultant told him to start me at 50mg/day, but I am wondering if he meant to start there to titrate higher rather than recommend remaining at 50mg as a trial dosage. In any event, my doctor wanted to see if I would respond to it. Perhaps they want to find the absolute minimum needed to reduce the risk of developing EPS and TD. I see him tomorrow. I think I'm going to ask him to move me up to 150mg/day, 50mg t.i.d.
Do you think 50mg of amisulpride = 100mg of sulpiride? Had you tried 25mg of amisulpride before raising the dosage to 50mg?
Your thoughts regarding presynaptic receptor priming are pretty cool. I just hope that staying on a low dose of sulpiride for 2 weeks hasn't reduced my chances of responding to it. I don't think it has. I had a thought (can you believe it?). I am wondering if experiencing initial sedation and somnolence with sulpiride or amisulpride is a prognosticator of non-response. Any thoughts?
(I had thought that I should have thought to find a word other than thought to use in place of the last thought, as I thought I had used the word thought too many times - or so I thought. I just hadn't thought of one.)
By the way, the explanation my doctor's consultant gave as to why he chose sulpiride over amisulpride is that he felt amisulpride was "too much of an antipsychotic". Amisulpride binds to D2 and D3 receptors with much greater affinity than sulpiride. I don't know how this might relate to his statement, but perhaps it reduces the "preference" for antagonizing presynaptic versus postsynaptic receptors.
My doctor told me that Sanofi is getting ready to start investigations of amisulpride in the U.S. for the treatment of depression/dysthymia.
I'm sorry to hear about your disappointment with your recent drug trials. I'm sure you'll come up with more of your innovative approaches. I'll be praying that you find what you're looking for.
With the sincerest of appreciation,
Scott
poster:SLS
thread:39176
URL: http://www.dr-bob.org/babble/20000630/msgs/39338.html