Posted by AndrewB on June 14, 2000, at 11:12:28
In reply to Re: Incomplete recovery - SLS » KarenB, posted by SLS on June 14, 2000, at 8:56:47
Bowl me over Scott. That information on sulpiride is so interesting. It sounds like you have a great psychiatrist working with you. Do you have any other information on sulpiride that he passed along to you. I'd like to know more. more, more.
Scott, clutch your lucky rabbit’s foot and hope that you are in the group that responds to sulpiride. I'm, as always, am hoping that the gods stop their conspiracy against you and, instead, let a shaft of ‘positive response to pharmacological therapy’ shine down upon you.
Scott, on another topic, I think it is clear that some of the positive action of dopaminergic drugs is due to upregulation of portions of the dopamine system and nothing more. A person apathetic from a stroke that damaged his frontl lobe is helped by the dopaminergic amantadine. The person with fatigue and poor concentration due to a strain of viral encephalitis that produced lesions upon his dopaminergic system is helped by bromcriptine. Isn’t it clear that certain aspects of anxiety, reward, motivation and mood lie within the limbic system and are modulated, at least in part, by D2/D3 receptors, and that damage to those parts of the brain or dysfunction of those receptors are the ultimate physiological cause of some mood and anxiety (and other) symptoms. We don’t have to always looks farther afield and say that the positive effect of a dopaminergic drug is due ultimately to modification of the HPA axis or some kind of masking effect upon that axis. Stress doesn’t just modify and damage the HPA axis. The effects of stress are global. For a better understanding of how stress in our lives can modify the dopaminergic system read the paper entitled, The role of stress in the pathophysiology of the dopaminergic system.’
(www.stockton-press.co.uk/server-java/Propub/stockton/spmp_v5_n1_p14_o1.fulltext)
Your serve Scott!Karen, I wanted to let you know about a paper on the net that talks about ADHD and drug treatment for it. It is very interesting. The author believes that ADHD is of dopaminergic origin as evidenced by his findings that selegiline and tyrosine, which both act solely on the dopamine system, were as effective as amphetamines on ADHD. This certainly would explain amineptine’s effectiveness for you. (BTW, I disagree with Scott that amineptine is a reuptake inhibtor of NE. It only is a reuptake inhibitor of dopamine. I think Peter J made it clear that there is an NE effect from amineptine but it is from some other mechanism than reuptake.......and how significant is it anyway?) You can find this paper at www.mhsource.com/pt/p960741.html
I wonder how a COMT inhibitor combined with selegiline would work for ADHD?
One final note. There is case reported where a women lost her menses due to sulpiride. When given bromocriptine, the menses returned. I presume this is due to bromocriptine’s ability to reverse the elavated prolactin level that sulpiride causes in women. From what I’ve read, the weight gain is also due to elevated prolactin levels and, thus, should be prevented by the tandem use of bromocriptine with one’s sulpiride. Bromocriptine is also available from that Indian pharmacy.
Scott, I tried l-dopa with entacapone and selegiline. Seemed to give me a very good arousal, but it’s just one day and my first impressions are often way of base. Problem is that l-dopa does, as the amisulpride’s label instructions warned, contradict (or take away) the action of amisulpride and thus cause the return of depression and related symptoms. I don’t know what I’ll do next. Probably I’ll take the l-dopa combo again and see if the same thing happens. Considering Tasmar, the other, stronger COMT.
AndrewB
poster:AndrewB
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URL: http://www.dr-bob.org/babble/20000610/msgs/37266.html