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Dr. Bob is Robert Hsiung, MD,
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Posted by medamorphosis on December 15, 2010, at 21:44:20
In reply to Re: Valdoxan (agomelatine) » Conundrum, posted by medamorphosis on December 15, 2010, at 20:33:39
Hang on hang on. Why am I thinking of diphehydramine, when I have plenty of amnitryptyline left over? Im sure 25 to 50mg would suffice to create the SRI conditions on which your theory is based.
I also still have plenty of trimipramine left. It has much different & more actions inc 5-HT2 antagonism. Lots of other effcts tho http://en.wikipedia.org/wiki/Trimipramine
Im not going to play with all that at once- Im actually trying to get better lol. But its nice to know what ur arsnel is ;) lol
Posted by Phillipa on December 15, 2010, at 21:52:24
In reply to Re: Valdoxan (agomelatine) » alchemy, posted by medamorphosis on December 15, 2010, at 21:29:30
Ron not that long ago posted of his success might want to google his name and babblemail him? Phillipa
Posted by medamorphosis on December 15, 2010, at 22:23:45
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by Phillipa on December 15, 2010, at 21:52:24
> Ron not that long ago posted of his success might want to google his name and babblemail him? Phillipa
Thanks, might do that :)
Posted by Conundrum on December 16, 2010, at 11:51:39
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by medamorphosis on December 15, 2010, at 21:44:20
An example of the important of SRI with 5 HT2 antagonism is Serzone. It is a potent 5 HT2 receptor antagonist even at low doses, but it is not until you get to the higher doses where there is more SRI that it starts to become an effective antidepressant. I don't know what you should add to help with the serotonin, or if it would definitely work. I would talk to your doctor, I don't know anything about what interacts with valdoxan.
Posted by medamorphosis on December 16, 2010, at 15:44:35
In reply to Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 13:42:27
So far so good- well no negatives. Though I have completely lost my appetite. Feels just like my 1st week on buspirone. I'm on a diet of whole milk & fruit, its all I can manage. ATM I dont consider this a negative. I need to loose a little weight. As long as it doesn't get worse I deal with it. Iteresting tho... Any ideas wich mechanism might be causing loss of appetite? Or maybe its a rebound from amitryptyline? Tho I had no particular apetite on that.
med
Posted by medamorphosis on December 16, 2010, at 16:42:57
In reply to Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 13:42:27
NOTE: Im not advacating at all, I just believe in free speach for eductional use only ;)
Anyway, One thing bizzare which happened yesterday is that after a few cannabis joints I was getting closed-eye hallucinations. I NEVER get them with cannabis alone. Melotonin playing a part? Hhmmm...
Posted by Conundrum on December 17, 2010, at 10:39:20
In reply to Re: Valdoxan + appetite, posted by medamorphosis on December 16, 2010, at 15:44:35
Could be the amitriptyline rebound. How long have you been off it?
> So far so good- well no negatives. Though I have completely lost my appetite. Feels just like my 1st week on buspirone. I'm on a diet of whole milk & fruit, its all I can manage. ATM I dont consider this a negative. I need to loose a little weight. As long as it doesn't get worse I deal with it. Iteresting tho... Any ideas wich mechanism might be causing loss of appetite? Or maybe its a rebound from amitryptyline? Tho I had no particular apetite on that.
>
> med
Posted by medamorphosis on December 17, 2010, at 10:57:14
In reply to Re: Valdoxan + appetite, posted by Conundrum on December 17, 2010, at 10:39:20
> Could be the amitriptyline rebound. How long have you been off it?
>
Since last Sunday, 5 days. Yet I never had appetite issues whilst i was on it. So perhapse this is withdrawal more than anythings elso, oh and im stil on liquids.
Posted by ed_uk2010 on December 18, 2010, at 9:06:16
In reply to Over 18s ONLY, posted by medamorphosis on December 16, 2010, at 16:42:57
>Re: Over 18s ONLY
Ya know, I went straight to this post (not sure what that says about me). I thought you were going to tell us something really REALLY bad.
Posted by medamorphosis on December 18, 2010, at 9:16:06
In reply to Re: Over 18s ONLY, posted by ed_uk2010 on December 18, 2010, at 9:06:16
> >Re: Over 18s ONLY
>
> Ya know, I went straight to this post (not sure what that says about me). I thought you were going to tell us something really REALLY bad.HA_HA! Sorry to disappoint ;) Though i could do if you like? Allways wanted to go on a huge robbing spree! :D
Posted by sigismund on December 18, 2010, at 14:54:21
In reply to Re: Over 18s ONLY, posted by ed_uk2010 on December 18, 2010, at 9:06:16
Yes. I had my hopes up too.
Posted by sigismund on December 18, 2010, at 15:00:23
In reply to Re: Over 18s ONLY » ed_uk2010, posted by medamorphosis on December 18, 2010, at 9:16:06
The improved sleep from agomelatine is gone with me, but I stll take it because of the push it gives me.
I cope much better with crappy sleep the day after with it.
I don't know what to do about the sleep thing, so I have decided to go with the flow.
Posted by medamorphosis on December 18, 2010, at 17:57:16
In reply to Re: Over 18s ONLY, posted by sigismund on December 18, 2010, at 15:00:23
> The improved sleep from agomelatine is gone with me, but I stll take it because of the push it gives me.
>
> I cope much better with crappy sleep the day after with it.
>
> I don't know what to do about the sleep thing, so I have decided to go with the flow.I have small stocks of old meds leftover (haven't we all?).
Ive already tried adding trimipramine, a particularly strong 5-HT2 agonist to agomelatine. Too many dreams for me in one night thankyou! But just showing it can be done. No toxic 'interaction' from what I felt. But I easily have bad/vivid dreams. It might be an excellent 5-HT2 agonist combo for some...
med
Posted by medamorphosis on December 18, 2010, at 17:59:36
In reply to Re: Valdoxan + appetite » Conundrum, posted by medamorphosis on December 17, 2010, at 10:57:14
Eating ok now. Feeling normally hungry thank god.
Posted by medamorphosis on December 22, 2010, at 10:44:17
In reply to Re: Valdoxan + appetite » medamorphosis, posted by medamorphosis on December 18, 2010, at 17:59:36
OK. Feels like the Valdoxan has settled now, and I like it! Certainly an improvement on my standard clonazepam + isocarboxazid combo. Feel more alive, tho my emotions are running wild. That is a good sign IMO. Means my brains working more 'normal'. Sad stuff can draw a tear or too. Excitement (about something exciting!) is raw yet refreshing. NO hypomania.
Just one 'issue'. Dreaming has become more vivid like with trimipramine, but feels more natural. Tho paralysis is present in the mornings. But it is cold. Maybe my body just wants to stay under the covers? lol
Posted by medamorphosis on December 22, 2010, at 10:46:47
In reply to Re: Valdoxan, posted by medamorphosis on December 22, 2010, at 10:44:17
Right, I have enough Valdoxan so up to 50mg me thinks! NOT doctor's orders, but I gotta try it. Even the literature says 50mg is the likely theraputic dose.
Posted by Travis on December 22, 2010, at 21:00:01
In reply to Re: Valdoxan (agomelatine), posted by medamorphosis on December 14, 2010, at 15:17:55
Posted by Phillipa on December 22, 2010, at 21:11:13
In reply to Re: Valdoxan, posted by medamorphosis on December 22, 2010, at 10:46:47
Good luck and keep posting. Phillipa
Posted by medamorphosis on December 23, 2010, at 22:31:29
In reply to Re: Valdoxan » medamorphosis, posted by Phillipa on December 22, 2010, at 21:11:13
> Good luck and keep posting. Phillipa
Thanx, and I will. merry Christmas!
Posted by Phillipa on December 23, 2010, at 22:40:23
In reply to Re: Valdoxan » Phillipa, posted by medamorphosis on December 23, 2010, at 22:31:29
Same to You Merry Christmas!!!! Phillipa
Posted by Ron Hill on December 30, 2010, at 19:13:35
In reply to Re: Valdoxan (agomelatine), posted by alchemy on December 15, 2010, at 21:05:50
Alchemy,
I wondered why my ears have been ringing. Now I know; my friend Alchemy mentioned my name.
> But I know it was a miracle for Ron Hill
The word "miracle" is perhaps an overstatement regarding the overall action of Valdoxan for me. For example, Valdoxan can cause daytime sleepiness for me, and this side effect is dose dependent. I added 2.5 mg/day of Adderal XL to treat this Valdoxan side effect. I'd like to take more Adderal XL, but stimulants cause me to become very irritable (GRRRRRRRRRRRR) except at a micro-dose level.
Further, I usually sleep well on Valdoxan. But, once in a while, for no apparent reason, my sleep is very shallow and choppy. Go figure.
Having said all that, however, Valdoxan is a MIRACLE for me because it stopped my ultra rapid cycling and, thereby, it also stopped my bipolar depression.
As you know, in addition to Valdoxan, I take several meds, vitamins, and supplements. Valdoxan alone would not adequately treat my bipolar II. It is the combo working synergistically.
For example, I always take my meds but, for reasons I do not fully understand, I often neglect taking my vitamins and supplements. If I skip my vitamins and supplements for two or three days in a row, I loose my energy and motivation, and I fall into a low grade depression. As soon as I take my vitamins and supplements, I snap out of it and am back to normal.
My point is that everything I take plays a part in keeping me well. However, if it were not for Valdoxan, I'd still be ultra rapid cycling and, thereby, severely depressed six out of every fifteen days, non-stop over, and over, and over ...
How are you, Alchemy? Any med changes? What does your p-doc say?
-- Ron
dx: Bipolar II and mild OCPD600 mg/day Trileptal (oxcarbazepine)
200 mg/day Lamictal (lamotrigine)
500 mg/day Keppra (levetiracetam)
90 mg/day Nardil (phenelzine)
12.5 mg at betime Valdoxan (agomelatine)
3.75 mg/day Deplin (taken with 2500 mcg/day of sublingual methyl B-12, and 12.5mg/day of sublingual P-5-P)
2.5 mg/day Adderal XR45 ml/day of Carlsons Bottled Fish Oil
100 mg/day phosphatidylserene
1 Centrum Chewable Multi-vitamin/day; Only 100% of all the usual vitamins; NO VANADIUM!!
2000 IU/day Vitamin D-3
850 mg/day of Mg 212% of RDA (as 5 grams of Mg Malate)
200 mcg/day GTF Chromium
600 mcg/day Chromium Picolinate
200 mg/day Co-Q10
1000 mg/day Cinnamon
480 mg/day Milk Thistle
2 g Vitamin C
Whats next to add?:
NAC, + 8 to 10 glasses of water, + Acetyl-L-Carnitine, + Alpha-Lipoic Acid
Posted by Ron Hill on December 30, 2010, at 19:26:49
In reply to Re: Valdoxan (agomelatine) » alchemy, posted by medamorphosis on December 15, 2010, at 21:29:30
Med,
> Is Ron Hill still on here? If you know him maybe youcould ask him to babblemail me?
Are you still taking Valdoxan? If so, how is it doing for you?
I'm tracking this thread now, so if you have questions for me, just post to this thread, and I will reply.
Belated Santa; Ho, Ho, Ho:
<[:-)}}
-- Ron
Posted by medamorphosis on December 31, 2010, at 2:50:58
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by Ron Hill on December 30, 2010, at 19:26:49
> Med,
>
> > Is Ron Hill still on here? If you know him maybe youcould ask him to babblemail me?
>
> Are you still taking Valdoxan? If so, how is it doing for you?
>
> I'm tracking this thread now, so if you have questions for me, just post to this thread, and I will reply.
>
> Belated Santa; Ho, Ho, Ho:
>
> <[:-)}}
>
> -- Ron
>
>
>Hi Ron. You know what? It just keeps gettin better! Dreamlems are stable, sleep is refreshing and I can actually wake up during am! Definitely a huge improvement! Will keep postin.
med
Posted by Ron Hill on December 31, 2010, at 20:51:54
In reply to Re: Valdoxan (agomelatine) » Ron Hill, posted by medamorphosis on December 31, 2010, at 2:50:58
Med,
> You know what? It just keeps gettin better! Dreamlems are stable, sleep is refreshing and I can actually wake up during am! Definitely a huge improvement! Will keep postin.
Excellent!
Are you taking 25 mg/night?
I take 12.5 because, in my case, 25 causes way too much daytime sedation (sleepy-tiredness). And, 12.5 mg/night is adequate to stop my ultra rapid cycling and, thereby, stopping my bipolar II depression. As a bonus, I cut my cost in half by taking 12.5 instead of 25.
I live in the U.S., and my insurance company will not pay for Valdoxan since it is not U.S. FDA approved. Therefore, I have to order it online and pay full price.
But, thank the Lord that I can order it online because it has made me well when nothing else has.
-- Ron
Posted by medamorphosis on January 1, 2011, at 14:08:11
In reply to Re: Valdoxan (agomelatine) » medamorphosis, posted by Ron Hill on December 31, 2010, at 20:51:54
> Med,
>
> > You know what? It just keeps gettin better! Dreamlems are stable, sleep is refreshing and I can actually wake up during am! Definitely a huge improvement! Will keep postin.
>
> Excellent!
>
> Are you taking 25 mg/night?
>
> I take 12.5 because, in my case, 25 causes way too much daytime sedation (sleepy-tiredness). And, 12.5 mg/night is adequate to stop my ultra rapid cycling and, thereby, stopping my bipolar II depression. As a bonus, I cut my cost in half by taking 12.5 instead of 25.
>
> I live in the U.S., and my insurance company will not pay for Valdoxan since it is not U.S. FDA approved. Therefore, I have to order it online and pay full price.
>
> But, thank the Lord that I can order it online because it has made me well when nothing else has.
>
> -- Ron
>
>
>Its certainly different to anything else. Lets hope poop-out potential is LOW!
BTW I take 50mg/night and no sedation next day at all. At least none from Valdoxan.
Pitty it costs so much for u but at least 12.5 is enough for you keeping it cheaper.
Happy New Yearmed
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