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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by rovers95 on October 31, 2010, at 17:46:23
http://clinicallypsyched.com/p11-gene-therapy-depression-treatment-mental-health-psychiatry-news/
Just wondering how long people think we are away for gene therapy for depression? I live in hope!!!
rover
Posted by SLS on October 31, 2010, at 18:43:56
In reply to gene therapy for depression, how far are we away?!, posted by rovers95 on October 31, 2010, at 17:46:23
> http://clinicallypsyched.com/p11-gene-therapy-depression-treatment-mental-health-psychiatry-news/
>
> Just wondering how long people think we are away for gene therapy for depression? I live in hope!!!
>
> roverI don't know, Rover. I've been waiting, too. I independently thought of using gene therapy as an alternative to treat affective disorders in 1992. At the time, the concept was revolutionary, although abstract. There were no known targets or vectors at the time. My doctors at the NIH thought the idea was pretty innovative, but far from being realized. I guess things are further along than I realized.
- Scott
Posted by Conundrum on October 31, 2010, at 23:08:43
In reply to gene therapy for depression, how far are we away?!, posted by rovers95 on October 31, 2010, at 17:46:23
Wow thats a great article. It was interesting where it said the brain can produce all the serotonin it wants, but it doesn't matter if there is no p11 receptor to bind to. Maybe this is why so many do not respond to SSRIs. They increase the serotonin but do not address the core problem. So once the mice are given the virus with the p11 protein will the mice continue to produce the gene/receptor or will they need to be constantly receiving the virus, like taking a drug routinely?
Posted by Phillipa on November 1, 2010, at 0:26:10
In reply to gene therapy for depression, how far are we away?!, posted by rovers95 on October 31, 2010, at 17:46:23
So some just don't produce a gene? Phillipa
Posted by SLS on November 1, 2010, at 5:03:13
In reply to Re: gene therapy for depression, how far are we away?! » rovers95, posted by Conundrum on October 31, 2010, at 23:08:43
> Wow thats a great article. It was interesting where it said the brain can produce all the serotonin it wants,
p11 is actually a gene. It directs the activity of the neurotransmitter reuptake molecule so that it is incorporated into the cell membrane in such a way so as to make it available for synaptic neurotransmitter to bind to and be transported back into the neuron. In the absence of p11, the transporter is ineffectual.
- Scott
Posted by Conundrum on November 1, 2010, at 11:14:23
In reply to Re: gene therapy for depression, how far are we away?!, posted by SLS on November 1, 2010, at 5:03:13
> > Wow thats a great article. It was interesting where it said the brain can produce all the serotonin it wants,
>
> p11 is actually a gene. It directs the activity of the neurotransmitter reuptake molecule so that it is incorporated into the cell membrane in such a way so as to make it available for synaptic neurotransmitter to bind to and be transported back into the neuron. In the absence of p11, the transporter is ineffectual.
>
>
> - ScottSo without the p11 gene, the reuptake of serotonin in to the cell is disrupted. Geez that doesn't sound at all familiar. Now fixing this is supposed to help with depression, when drugs do the opposite?
Posted by SLS on November 1, 2010, at 12:33:28
In reply to Re: gene therapy for depression, how far are we away?!, posted by Conundrum on November 1, 2010, at 11:14:23
> > > Wow thats a great article. It was interesting where it said the brain can produce all the serotonin it wants,
> >
> > p11 is actually a gene. It directs the activity of the neurotransmitter reuptake molecule so that it is incorporated into the cell membrane in such a way so as to make it available for synaptic neurotransmitter to bind to and be transported back into the neuron. In the absence of p11, the transporter is ineffectual.
> >
> >
> > - Scott
>
> So without the p11 gene, the reuptake of serotonin in to the cell is disrupted. Geez that doesn't sound at all familiar. Now fixing this is supposed to help with depression, when drugs do the opposite?Low p11 = depression?
Ostensibly, one would think that without sufficient p11 activity, the presynaptic stores of neurotransmitter would become depleted and incapable of keeping up with the signals (action potentials) of upstream neurons. That's just a guess, though.
- Scott
Posted by bleauberry on November 3, 2010, at 5:08:42
In reply to gene therapy for depression, how far are we away?!, posted by rovers95 on October 31, 2010, at 17:46:23
I think we are pretty close. A small handful of specialists are already there. For the masses to catch on will probably take another 20 years.
I say that because my own genetic testing was the biggest thing that showed my doctor and me where the biological problems are and what supplements would be best at building new pathways around those roadblocks. 60% better within one week, more improvement than at any time in the previous 20 years of psych meds. All from genetic testing. Other tests, such as specific blood tests, stool tests, and urine tests...most by Genova Diagnostics....confirmed and reinforced the genetic profile.
So, it's already happening.
Posted by rovers95 on November 3, 2010, at 20:29:05
In reply to Re: gene therapy for depression, how far are we away?!, posted by bleauberry on November 3, 2010, at 5:08:42
> I think we are pretty close. A small handful of specialists are already there. For the masses to catch on will probably take another 20 years.
>
> I say that because my own genetic testing was the biggest thing that showed my doctor and me where the biological problems are and what supplements would be best at building new pathways around those roadblocks. 60% better within one week, more improvement than at any time in the previous 20 years of psych meds. All from genetic testing. Other tests, such as specific blood tests, stool tests, and urine tests...most by Genova Diagnostics....confirmed and reinforced the genetic profile.
>
> So, it's already happening.Hey so what is this geenetic testing and how do you get it....im intriged!!
thanks
rover
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