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Re: gene therapy for depression, how far are we away?! » Conundrum

Posted by SLS on November 1, 2010, at 12:33:28

In reply to Re: gene therapy for depression, how far are we away?!, posted by Conundrum on November 1, 2010, at 11:14:23

> > > Wow thats a great article. It was interesting where it said the brain can produce all the serotonin it wants,
> >
> > p11 is actually a gene. It directs the activity of the neurotransmitter reuptake molecule so that it is incorporated into the cell membrane in such a way so as to make it available for synaptic neurotransmitter to bind to and be transported back into the neuron. In the absence of p11, the transporter is ineffectual.
> >
> >
> > - Scott
>
> So without the p11 gene, the reuptake of serotonin in to the cell is disrupted. Geez that doesn't sound at all familiar. Now fixing this is supposed to help with depression, when drugs do the opposite?

Low p11 = depression?

Ostensibly, one would think that without sufficient p11 activity, the presynaptic stores of neurotransmitter would become depleted and incapable of keeping up with the signals (action potentials) of upstream neurons. That's just a guess, though.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

 

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