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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by zzzz7 on June 6, 2010, at 23:27:17
Have any of you tried low dose aminoglutethimide or ketoconazole for treatment of depression?
My own depression tracks cortisol spikes exactly (I was amazed when I looked in an endocrinology textbook at a graph of cortisol release--all the spikes in the graph were exactly where I got most depressed during the day). It also gets worse when I exercise, and it gets better for 20 minutes or so when I take a low dose of DHEA.
Any thoughts/suggestions would be most welcome. Thanks.
Posted by desolationrower on June 7, 2010, at 9:54:11
In reply to Low dose aminoglutethimide or ketoconazole ?, posted by zzzz7 on June 6, 2010, at 23:27:17
well i haven't calculate just what the 'dose' is but i use ketaconazole shampoo; it reduces hair loss. its a pretty strong antiandrogen.do you think you've got cushings?
-d/r
Posted by jade k on June 7, 2010, at 16:23:36
In reply to Re: Low dose aminoglutethimide or ketoconazole ?, posted by desolationrower on June 7, 2010, at 9:54:11
> well i haven't calculate just what the 'dose' is but i use ketaconazole shampoo
>
> -d/rCool, so u reduce hair loss and depression with one product?
~Jade (hi d/r)
Posted by rovers95 on June 7, 2010, at 17:14:34
In reply to Low dose aminoglutethimide or ketoconazole ?, posted by zzzz7 on June 6, 2010, at 23:27:17
This med looks like quite a good shout, suprised there aren't more posts on it. My only worry would be, is it safe with clonazepam....i think they are both broke down by the same enzyme or something?
cheers
rover
Posted by bleauberry on June 7, 2010, at 18:28:20
In reply to Low dose aminoglutethimide or ketoconazole ?, posted by zzzz7 on June 6, 2010, at 23:27:17
Ketaconazole I am not familiar with , except that it is a close relative of Diflucan. The two are supposedly very similar, except that diflucan is safer and less finnicky.
All I know is, from the first day of taking diflucan for suspected fungal issues, I immediately noticed mood improvement more pronounced than an antidepressant. Why or how, other than killing fungus/yeast, I have no idea. It just is.
Trying to get the right dose, I started out at 200mg a day but have since discovered 50mg once every 2 or 3 days is good. It is very long lasting and accumulates.
Posted by desolationrower on June 7, 2010, at 20:47:52
In reply to Re: Low dose aminoglutethimide or ketoconazole ? » desolationrower, posted by jade k on June 7, 2010, at 16:23:36
> > well i haven't calculate just what the 'dose' is but i use ketaconazole shampoo
> >
> > -d/r
>
> Cool, so u reduce hair loss and depression with one product?
>
> ~Jade (hi d/r)
>
>
>hi. how are you.
i wouldn't want to take taht much - it totally stops up androgen function. i'll take a feminine scalp though
-d/r
Posted by Phillipa on June 7, 2010, at 22:07:42
In reply to Re: Low dose aminoglutethimide or ketoconazole ?, posted by desolationrower on June 7, 2010, at 20:47:52
Jade you are back. Write. Phillipa
Posted by zzzz7 on June 8, 2010, at 3:35:08
In reply to Re: Low dose aminoglutethimide or ketoconazole ? » desolationrower, posted by jade k on June 7, 2010, at 16:23:36
Thanks all for the responses. The drug is an anti-fungal and is the active ingredient in Nizoral shampoo (that is, ketoconazole is).
I don't think I have Cushings. I think that something--high-dose SSRIs, depression, Provigil, benzo use--something--has caused me to be very sensitive to sudden spikes in cortisol levels. So if I can even out the spikes, or reduce them once they occur, I hopefully will feel better.
I'm steadily better on 3.75mg of mirtazapine after not being able to take any other antidepressant because they made me depressed. (This was a sudden shift after years of taking 110mg of Prozac and other high doses of SSRIs.)
Posted by jade k on June 8, 2010, at 14:44:02
In reply to Re: Low dose aminoglutethimide or ketoconazole ?, posted by Phillipa on June 7, 2010, at 22:07:42
> Jade you are back. Write. Phillipa
Hey Phillipa, I lost my contacts a long time ago along with my old email address. Not sure if I get babble mail now or not.
~Jade
Posted by Phillipa on June 8, 2010, at 16:54:25
In reply to Re: Low dose aminoglutethimide or ketoconazole ? » Phillipa, posted by jade k on June 8, 2010, at 14:44:02
Jade to get babblmails go to registration turn on babblemail name in blue. Mine is on. Phillipa would love to chat as still talk to some you know
Posted by rovers95 on June 8, 2010, at 17:19:50
In reply to Re: Low dose aminoglutethimide or ketoconazole ?, posted by bleauberry on June 7, 2010, at 18:28:20
> Ketaconazole I am not familiar with , except that it is a close relative of Diflucan. The two are supposedly very similar, except that diflucan is safer and less finnicky.
>
> All I know is, from the first day of taking diflucan for suspected fungal issues, I immediately noticed mood improvement more pronounced than an antidepressant. Why or how, other than killing fungus/yeast, I have no idea. It just is.
>
> Trying to get the right dose, I started out at 200mg a day but have since discovered 50mg once every 2 or 3 days is good. It is very long lasting and accumulates.
>hey bleauberry, did you/have you used with benzos - as they are both effected by enzyme cytochrome p450....and apparently this can spell trouble.
cheers
rover
This is the end of the thread.
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